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Its great to have competition in the market, said Tan, who is chair of metabolic medicine and endocrinology at Imperial College London

Combining the results from 37 different studies involving over 2,000 people, L-carnitine supplementation led to an average weight loss of about 1.2 kg (roughly 2.7 pounds), a small drop in BMI (0.24 kg/m), and a reduction in fat mass by about 2 kg

Hsieh MJ, Tsai TL, Hsieh YH, Huang CY, Wang CJ, Hsu YH

412 Notably, GLP-1RAs, including exendin-4, have been shown to attenuate microglial activation, resulting in a reduction in the expression of proinflammatory cytokines such as TNF- and IL-1

While research on how to activate autophagy and its potential benefits is still evolving, a standard 3 to 5 gram dose of pure creatine monohydrate is unlikely to have a meaningful impact